Nobis Lab Epilepsy research at VUMC

Publications

2024

Near SUDEP in a patient with craniosynostosis syndrome and temporal lobe encephaloceles
Near SUDEP in a patient with craniosynostosis syndrome and temporal lobe encephaloceles
Joseph Ta, Christopher Smith, Nyasia Mayaudon Finley, Martin Gallagher, Andre LaGrange, Kelly Lowen, Trevor Meyer, Vivek Ganesh, Jay V. Shah, William Nobis
Epileptic Disorders   ·   13 Nov 2024   ·   doi:10.1002/epd2.20304
512 Odorant exposure decreases mortality in a Dravet Syndrome mouse model
512 Odorant exposure decreases mortality in a Dravet Syndrome mouse model
William Nobis, Ragan Huffman, Alyssa Mitchell, Martina Hannalla
Journal of clinical and translational science   ·   01 Mar 2024   ·   pmc:PMC10126895

2023

Narrowing the translational research gap by aligning replication concepts in basic and clinical neuroscience
Narrowing the translational research gap by aligning replication concepts in basic and clinical neuroscience
Alan S. Lewis, William P. Nobis
Journal of Neuroscience Methods   ·   01 May 2023   ·   doi:10.1016/j.jneumeth.2023.109878
Acute manganese exposure impairs glutamatergic function in a young mouse model of Alzheimer’s disease
Acute manganese exposure impairs glutamatergic function in a young mouse model of Alzheimer’s disease
Brittany D. Spitznagel, Rebecca A. Buchanan, David C. Consoli, Megan K. Thibert, Aaron B. Bowman, William P. Nobis, Fiona E. Harrison
NeuroToxicology   ·   01 Mar 2023   ·   doi:10.1016/j.neuro.2023.01.002
Epilepsy with anterior temporal encephaloceles: Baseline characteristics, post-surgical outcomes, and comparison to mesial temporal sclerosis
Epilepsy with anterior temporal encephaloceles: Baseline characteristics, post-surgical outcomes, and comparison to mesial temporal sclerosis
Niyatee Samudra, Eric Armour, Hernan Gonzalez, Danielle Mattingly, Kevin Haas, ..., Joseph M. Aulino, Sarah Bick, Victoria Morgan, Dario Englot, Bassel Abou-Khalil
Epilepsy & Behavior   ·   01 Feb 2023   ·   doi:10.1016/j.yebeh.2022.109061
Altered EEG, disrupted hippocampal long-term potentiation and neurobehavioral deficits implicate a delirium-like state in a mouse model of sepsis
Altered EEG, disrupted hippocampal long-term potentiation and neurobehavioral deficits implicate a delirium-like state in a mouse model of sepsis
David C. Consoli, Brittany D. Spitznagel, Benjamin M. Owen, Hakmook Kang, Shawniqua Williams Roberson, Pratik Pandharipande, E. Wesley Ely, William P. Nobis, Julie A. Bastarache, Fiona E. Harrison
Brain, Behavior, and Immunity   ·   01 Jan 2023   ·   doi:10.1016/j.bbi.2022.10.003

2022

30-Day readmission rates in pediatric patients with functional seizures
30-Day readmission rates in pediatric patients with functional seizures
Jonah Fox, Shilpa B. Reddy, William P. Nobis
Epilepsy & Behavior   ·   01 Dec 2022   ·   doi:10.1016/j.yebeh.2022.108956
Glucagon‐like peptide‐1 receptor differentially controls mossy cell activity across the dentate gyrus longitudinal axis
Glucagon‐like peptide‐1 receptor differentially controls mossy cell activity across the dentate gyrus longitudinal axis
Alex Steiner, Benjamin M. Owen, James P. Bauer, Leann Seanez, Sam Kwon, Jessica E. Biddinger, Ragan Huffman, Julio E. Ayala, William P. Nobis, Alan S. Lewis
Hippocampus   ·   05 Sep 2022   ·   doi:10.1002/hipo.23469
Glucagon-like peptide-1 receptor differentially controls mossy cell activity across the dentate gyrus longitudinal axis
Glucagon-like peptide-1 receptor differentially controls mossy cell activity across the dentate gyrus longitudinal axis
Alex Steiner, Benjamin M. Owen, James P. Bauer, Leann Seanez, Sam Kwon, Jessica E. Biddinger, Ragan Huffman, Julio E. Ayala, William P. Nobis, Alan S. Lewis
Cold Spring Harbor Laboratory   ·   17 Mar 2022   ·   doi:10.1101/2022.03.14.484169
Disruption of Synaptic Transmission in the Bed Nucleus of the Stria Terminalis Reduces Seizure-Induced Death in DBA/1 Mice and Alters Brainstem E/I Balance
Disruption of Synaptic Transmission in the Bed Nucleus of the Stria Terminalis Reduces Seizure-Induced Death in DBA/1 Mice and Alters Brainstem E/I Balance
Maya Xia, Benjamin Owen, Jeremy Chiang, Alyssa Levitt, Katherine Preisinger, Wen Wei Yan, Ragan Huffman, William P. Nobis
ASN Neuro   ·   01 Jan 2022   ·   doi:10.1177/17590914221103188

2021

Disruption of synaptic transmission in the Bed Nucleus of the Stria Terminalis reduces seizure-induced death in DBA/1 mice and alters brainstem E/I balance
Disruption of synaptic transmission in the Bed Nucleus of the Stria Terminalis reduces seizure-induced death in DBA/1 mice and alters brainstem E/I balance
Maya Xia, Benjamin Owen, Jeremy Chiang, Alyssa Levitt, Wen Wei Yan, William P. Nobis
Cold Spring Harbor Laboratory   ·   24 Dec 2021   ·   doi:10.1101/2021.12.23.473665
Altered synaptic glutamate homeostasis contributes to cognitive decline in young APP/PSEN1 mice
Altered synaptic glutamate homeostasis contributes to cognitive decline in young APP/PSEN1 mice
J.M. Wilcox, D.C. Consoli, A.A. Tienda, S. Dixit, R.A. Buchanan, J.M. May, W.P. Nobis, F.E. Harrison
Neurobiology of Disease   ·   01 Oct 2021   ·   doi:10.1016/j.nbd.2021.105486
Enhanced Synaptic Transmission in the Extended Amygdala and Altered Excitability in an Extended Amygdala to Brainstem Circuit in a Dravet Syndrome Mouse Model
Enhanced Synaptic Transmission in the Extended Amygdala and Altered Excitability in an Extended Amygdala to Brainstem Circuit in a Dravet Syndrome Mouse Model
Wen Wei Yan, Maya Xia, Jeremy Chiang, Alyssa Levitt, Nicole Hawkins, Jennifer Kearney, Geoffrey T. Swanson, Dane Chetkovich, William P. Nobis
eneuro   ·   01 May 2021   ·   doi:10.1523/ENEURO.0306-20.2021
Near SUDEP during bilateral stereo‐EEG monitoring characterized by diffuse postictal EEG suppression
Near SUDEP during bilateral stereo‐EEG monitoring characterized by diffuse postictal EEG suppression
Michael Johnson, Niyatee Samudra, Martin J. Gallagher, Bassel Abou‐Khalil, William P. Nobis
Epilepsia   ·   22 Feb 2021   ·   doi:10.1111/epi.16852

2020

Enhanced synaptic transmission in the extended amygdala and altered excitability in an extended amygdala to brainstem circuit in a Dravet syndrome mouse model
Enhanced synaptic transmission in the extended amygdala and altered excitability in an extended amygdala to brainstem circuit in a Dravet syndrome mouse model
Wen Wei Yan, Maya Xia, Alyssa Levitt, Nicole Hawkins, Jennifer Kearney, Geoffrey T. Swanson, Dane Chetkovich, William P. Nobis
Cold Spring Harbor Laboratory   ·   01 Sep 2020   ·   doi:10.1101/2020.09.01.267112
The effect of seizure spread to the amygdala on respiration and onset of ictal central apnea
The effect of seizure spread to the amygdala on respiration and onset of ictal central apnea
William P. Nobis, Karina A. González Otárula, Jessica W. Templer, Elizabeth E. Gerard, Stephen VanHaerents, Gregory Lane, Guangyu Zhou, Joshua M. Rosenow, Christina Zelano, Stephan Schuele
Journal of Neurosurgery   ·   01 May 2020   ·   doi:10.3171/2019.1.jns183157

2018

Amygdala‐stimulation‐induced apnea is attention and nasal‐breathing dependent
Amygdala‐stimulation‐induced apnea is attention and nasal‐breathing dependent
William P. Nobis, Stephan Schuele, Jessica W. Templer, Guangyu Zhou, Gregory Lane, Joshua M. Rosenow, Christina Zelano
Annals of Neurology   ·   01 Mar 2018   ·   doi:10.1002/ana.25178

2017

Excitatory Synaptic Input to Hilar Mossy Cells under Basal and Hyperexcitable Conditions
Excitatory Synaptic Input to Hilar Mossy Cells under Basal and Hyperexcitable Conditions
Tristan P. Hedrick, William P. Nobis, Kendall M. Foote, Toshiyuki Ishii, Dane M. Chetkovich, Geoffrey T. Swanson
eneuro   ·   01 Nov 2017   ·   doi:10.1523/ENEURO.0364-17.2017

2011

β-Adrenergic Receptors Enhance Excitatory Transmission in the Bed Nucleus of the Stria Terminalis Through a Corticotrophin-Releasing Factor Receptor–Dependent and Cocaine-Regulated Mechanism
β-Adrenergic Receptors Enhance Excitatory Transmission in the Bed Nucleus of the Stria Terminalis Through a Corticotrophin-Releasing Factor Receptor–Dependent and Cocaine-Regulated Mechanism
William P. Nobis, Thomas L. Kash, Yuval Silberman, Danny G. Winder
Biological Psychiatry   ·   01 Jun 2011   ·   doi:10.1016/j.biopsych.2010.12.030

2010

Distinct forms of G <sub>q</sub> -receptor-dependent plasticity of excitatory transmission in the BNST are differentially affected by stress
Distinct forms of G q -receptor-dependent plasticity of excitatory transmission in the BNST are differentially affected by stress
Zoé A. McElligott, Jason R. Klug, William P. Nobis, Sachin Patel, Brad A. Grueter, Thomas L. Kash, Danny G. Winder
Proceedings of the National Academy of Sciences   ·   14 Jan 2010   ·   doi:10.1073/pnas.0905568107

2008

Dopamine Enhances Fast Excitatory Synaptic Transmission in the Extended Amygdala by a CRF-R1-Dependent Process
Dopamine Enhances Fast Excitatory Synaptic Transmission in the Extended Amygdala by a CRF-R1-Dependent Process
Thomas L. Kash, William P. Nobis, Robert T. Matthews, Danny G. Winder
The Journal of Neuroscience   ·   17 Dec 2008   ·   doi:10.1523/jneurosci.4715-08.2008

2004

Structure of the Bovine Natural Resistance Associated Macrophage Protein (<i>NRAMP 1</i>) Gene and Identification of a Novel Polymorphism
Structure of the Bovine Natural Resistance Associated Macrophage Protein (NRAMP 1) Gene and Identification of a Novel Polymorphism
Paul M. Coussens, Matthew J. Coussens, Brian C. Tooker, William Nobis
DNA Sequence   ·   01 Feb 2004   ·   doi:10.1080/10425170310001638945

2003

Development of a porcine brain cDNA library, EST database, and microarray resource
Development of a porcine brain cDNA library, EST database, and microarray resource
William Nobis, Xiaoning Ren, Steven P. Suchyta, Thomas R. Suchyta, Adroaldo J. Zanella, Paul M. Coussens
Physiological Genomics   ·   16 Dec 2003   ·   doi:10.1152/physiolgenomics.00099.2003

2002

Bioinformatics and high throughput approach to create genomic resources for the study of bovine immunobiology
Bioinformatics and high throughput approach to create genomic resources for the study of bovine immunobiology
Paul M. Coussens, William Nobis
Veterinary Immunology and Immunopathology   ·   01 Jul 2002   ·   doi:10.1016/s0165-2427(02)00005-3